Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings

Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings

Type I Interferons (IFN-I) are a family of potent antiviral cytokines that act through the direct restriction of viral replication and by enhancing antiviral immunity. However, these powerful cytokines are a caged lion, as excessive and sustained IFN-I production can drive immunopathology during inf...

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Bibliographic Details
Main Authors: Trever T. Greene, Elina I. Zuniga
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Viruses
Subjects:
IFN-I
plasmacytoid dendritic cells
viral infection
LCMV
influenza
HIV-1
Online Access:https://www.mdpi.com/1999-4915/13/9/1839

Internet

https://www.mdpi.com/1999-4915/13/9/1839

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