Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions

Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions

Abstract Background Eukaryotic initiation factor 2B (eIF2B) initiates and regulates translation initiation in eukaryotes. eIF2B gene mutations cause leukoencephalopathy called vanishing white matter disease (VWM) in humans and slow growth (Slg−) and general control derepression (Gcd−) phenotypes in...

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Bibliographic Details
Main Authors: Sonum Sharma, Anuradha Sourirajan, David J. Baumler, Kamal Dev
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
S. cerevisiae
eIF2B
VWM
Suppression
Identification
Emc4p
Online Access:http://link.springer.com/article/10.1186/s43141-020-00029-7

Internet

http://link.springer.com/article/10.1186/s43141-020-00029-7

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