Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Cell-Penetrating Peptides as a Tool for the Cellular Uptake of a Genetically Modified Nitroreductase for use in Directed Enzyme Prodrug Therapy

Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating enzyme to a solid tumour site, followed by the subsequent activation of an administered prodrug. One of the most studied enzyme&#8722;prodrug combinations is the nitroreductase from <i>Escherichia coli<...

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Bibliographic Details
Main Authors: Simon D. Anderson, Robert J. Hobbs, Vanessa V. Gwenin, Patrick Ball, Lindsey A. Bennie, Jonathan A. Coulter, Chris D. Gwenin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Functional Biomaterials
Subjects:
nitroreductase
cell-penetrating peptide
prodrug therapy
darkfield imaging
nanoparticle
Online Access:https://www.mdpi.com/2079-4983/10/4/45

Internet

https://www.mdpi.com/2079-4983/10/4/45

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