Analysis of the F2LR3 (PAR4) Single Nucleotide Polymorphism (rs773902) in an Indigenous Australian Population

Analysis of the F2LR3 (PAR4) Single Nucleotide Polymorphism (rs773902) in an Indigenous Australian Population

The F2RL3 gene encoding protease activated receptor 4 (PAR4) contains a single nucleotide variant, rs773902, that is functional. The resulting PAR4 variants, Thr120, and Ala120, are known to differently affect platelet reactivity to thrombin. Significant population differences in the frequency of th...

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Bibliographic Details
Main Authors: Dian Ningtyas, Russell J. Thomson, Volga Tarlac, Shivashankar H. Nagaraj, Wendy Hoy, John D. Mathews, Simon J. Foote, Elizabeth E. Gardiner, Justin R. Hamilton, Brendan J. McMorran
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Genetics
Subjects:
protease activated receptor 4
rs773902
renal disease
Australian Aboriginal and Torres Strait Islanders
indigenous genetics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00432/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00432/full

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