Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Insertion/deletion-activated frame-shift fluorescence protein is a sensitive reporter for genomic DNA editing

Abstract Background Reporter methods to quantitatively measure the efficiency and specificity of genome editing tools are important for the development of novel editing techniques and successful applications of available ones. However, the existing methods have major limitations in sensitivity, accu...

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Bibliographic Details
Main Authors: Akhilesh Kumar, Michael D. Birnbaum, Balaji T. Moorthy, Jayanti Singh, Anna Palovcak, Devang M. Patel, Fangliang Zhang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Insertion-deletion
In-del
Reporter
CRIPSR-Cas9
Genome editing
NHEJ
Online Access:http://link.springer.com/article/10.1186/s12864-019-5963-z

Internet

http://link.springer.com/article/10.1186/s12864-019-5963-z

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