Using a sequential regimen to eliminate bacteria at sublethal antibiotic dosages.

We need to find ways of enhancing the potency of existing antibiotics, and, with this in mind, we begin with an unusual question: how low can antibiotic dosages be and yet bacterial clearance still be observed? Seeking to optimise the simultaneous use of two antibiotics, we use the minimal dose at w...

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Bibliographic Details
Main Authors: Ayari Fuentes-Hernandez, Jessica Plucain, Fabio Gori, Rafael Pena-Miller, Carlos Reding, Gunther Jansen, Hinrich Schulenburg, Ivana Gudelj, Robert Beardmore
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4390231?pdf=render