Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency

Distinct Enhancer Activity of Oct4 in Naive and Primed Mouse Pluripotency

Naive and primed pluripotent stem cells (PSCs) and germ cells express the Oct4 gene. The Oct4 gene contains two cis-regulatory elements, the distal enhancer (DE) and proximal enhancer (PE), which differentially control Oct4 expression in a cell-type-specific and stage-specific manner. Here, we gener...

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Bibliographic Details
Main Authors: Hyun Woo Choi, Jin Young Joo, Yean Ju Hong, Jong Soo Kim, Hyuk Song, Jeong Woong Lee, Guangming Wu, Hans R. Schöler, Jeong Tae Do
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Stem Cell Reports
Subjects:
naive pluripotency
primed pluripotency
Oct4
enhancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116302181

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http://www.sciencedirect.com/science/article/pii/S2213671116302181

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