Embryotoxic activity of 3C protease of human hepatitis A virus in developing Danio rerio embryos

Abstract The 3C protease is a key factor in picornavirus-induced pathologies with a comprehensive action on cell targets. However, the effects induced by the enzyme have not been described at the organismic level. Here, the model of developing Danio rerio embryos was used to analyze possible toxic e...

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Bibliographic Details
Main Authors: Polina I. Selina, Maria A. Karaseva, Alexey A. Komissarov, Dina R. Safina, Nataliya A. Lunina, Marina P. Roschina, Eugene D. Sverdlov, Ilya V. Demidyuk, Sergey V. Kostrov
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97641-5