A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer

Background: Cancer patients often display dysfunctional antitumor T-cell responses. Because noteworthy benefits of immune checkpoint pathway blockade, such as programmed cell death protein 1 (PD-1) inhibitors, have been achieved in multiple advanced cancers, the next critical question is which mono-...

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Bibliographic Details
Main Authors: Xi Li, Rouzheng Wang, Peiwen Fan, Xuan Yao, Ling Qin, Yanchun Peng, Miaomiao Ma, Neil Asley, Xuimei Chang, Yaning Feng, Yunhui Hu, Yonghong Zhang, Chris Li, Gregory Fanning, Stephanie Jones, Clare Verrill, David Maldonado-Perez, Paul Sopp, Craig Waugh, Stephen Taylor, Simon Mcgowan, Vincenzo Cerundolo, Christopher Conlon, Andrew McMichael, Shichun Lu, Xiyan Wang, Ning Li, Tao Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
T cells
inhibitory receptor
tumor-infiltrating lymphocytes
tumor microenvironment
combinatorial checkpoint blockade
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01066/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01066/full

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