Ginsenoside Rh2 Induces Human Hepatoma Cell Apoptosisvia Bax/Bak Triggered Cytochrome C Release and Caspase-9/Caspase-8 Activation

Ginsenoside Rh2 Induces Human Hepatoma Cell Apoptosisvia Bax/Bak Triggered Cytochrome C Release and Caspase-9/Caspase-8 Activation

Ginsenoside Rh2 (G-Rh2) has been shown to induce apoptotic cell death in a variety of cancer cells. However, the details of the signal transduction cascade involved in G-Rh2-induced cell death is unclear. In this manuscript we elucidate the molecular mechanism of G-Rh2-induced apoptosis in human hep...

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Bibliographic Details
Main Authors: Xiao-Xi Guo, Qiao Guo, Yang Li, Seung Ki Lee, Xue-Ning Wei, Ying-Hua Jin
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
Bax/Bak translocation
caspase activation cascade
caspase-8/Bid pathway
ginsenoside Rh2
Online Access:http://www.mdpi.com/1422-0067/13/12/15523

Internet

http://www.mdpi.com/1422-0067/13/12/15523

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