Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Abstract Background Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against hepatic lipotoxicity are largely unc...

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Bibliographic Details
Main Authors: Tiantian Xu, Qing Song, Li Zhou, Wenwen Yang, Xiangyao Wu, Qianyu Qian, Hui Chai, Qiang Han, Hongzhi Pan, Xiaobing Dou, Songtao Li
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Nutrition & Metabolism
Subjects:
Ferulic acid
SIRT1
Autophagy
Lipotoxicity
Metabolic diseases
Online Access:https://doi.org/10.1186/s12986-021-00540-9

Internet

https://doi.org/10.1186/s12986-021-00540-9

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