Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis

Asymmetric synthesis of CF2-functionalized aziridines by combined strong Brønsted acid catalysis

A diastereo- and enantioselective approach to access chiral CF2-functionalized aziridines from difluorodiazoethyl phenyl sulfone (PhSO2CF2CHN2) and in situ-formed aldimines is described. This multicomponent reaction is enabled by a combined strong Brønsted acid catalytic platform consisting of a chi...

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Bibliographic Details
Main Authors: Xing-Fa Tan, Fa-Guang Zhang, Jun-An Ma
Format: Article
Language:English
Published: Beilstein-Institut 2020-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
aziridines
chiral disulfonimides
difluoromethyl compounds
fluorinated diazo reagents
strong brønsted acids
Online Access:https://doi.org/10.3762/bjoc.16.60

Internet

https://doi.org/10.3762/bjoc.16.60

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