Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing

Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF-α Regulation and Myocardial Healing

Phospholipase D1 is a regulator of tumor necrosis factor-α expression and release upon LPS-induced sepsis and following myocardial infarction (MI). Lack of PLD1 leads to a reduced TNF-α mediated inflammatory response and to enhanced infarct size with declined cardiac function 21 days after ischemia...

Full description

Bibliographic Details
Main Authors: Meike Klier, Simone Gorressen, Marc-Andre Urbahn, David Barbosa, Margriet Ouwens, Jens W. Fischer, Margitta Elvers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Physiology
Subjects:
PLD
enzymatic activity
myocardial infarction
ischemia
TNF-α
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01698/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01698/full

Similar Items