Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of l...

Full description

Bibliographic Details
Main Authors: Alexis Dumortier, André-Dante Durham, Matteo Di Piazza, Sophie Vauclair, Ute Koch, Gisèle Ferrand, Isabel Ferrero, Shadmehr Demehri, Lynda Li Song, Andrew G Farr, Warren J Leonard, Raphael Kopan, Lucio Miele, Daniel Hohl, Daniela Finke, Freddy Radtke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2823782?pdf=render

Internet

http://europepmc.org/articles/PMC2823782?pdf=render

Similar Items