Protocol to Generate and Characterize Potent and Selective WNT Mimetic Molecules

SUMMARY: WNT signaling is crucial for embryonic development, adult tissue homeostasis, and injury repair. The poor biophysical characteristics of WNTs and their lack of receptor selectivity have hindered their use as research tools or potential therapeutics. We have developed a platform to generate...

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Bibliographic Details
Main Authors: Hui Chen, Chenggang Lu, Sung-Jin Lee, Yang Li
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:STAR Protocols
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166720300307