Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in <i>EZH2</i> Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in <i>EZH2</i> Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates genes involved in cell lineage and differentiation through methylating lysine 27 on histone H3 (H3K27me3). Recurrent gain-of-function mutations of <i>EZH2&...

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Bibliographic Details
Main Authors: Sungryul Park, Seung-Hyun Jo, Jong-Hwan Kim, Seon-Young Kim, Jae Du Ha, Jong Yeon Hwang, Myeong Youl Lee, Jong Soon Kang, Tae-Su Han, Sung Goo Park, Sunhong Kim, Byoung Chul Park, Jeong-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
PRC2
EZH2
GSK126
pomalidomide
IMiD
DLBCL
Online Access:https://www.mdpi.com/2072-6694/12/9/2541

Internet

https://www.mdpi.com/2072-6694/12/9/2541

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