Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease

Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease

Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the molecular mechanism of renal lipotoxicity remains...

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Bibliographic Details
Main Authors: Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-12-01
Series:JCI Insight
Subjects:
Metabolism
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.140483

Internet

https://doi.org/10.1172/jci.insight.140483

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