Deciphering the resistance mechanism of RET kinase mutant against vandetanib and nintedanib using molecular dynamics simulations

Deciphering the resistance mechanism of RET kinase mutant against vandetanib and nintedanib using molecular dynamics simulations

The RET protein is a transmembrane receptor tyrosine kinase (RTK) whose oncogenic mutations or fusions are closely related to human cancers such as thyroid and non-small cell lung cancer. Vandetanib as a clinical-approved protein-tyrosine kinase inhibitor (TKI) exhibits anti-cancer efficacy by block...

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Bibliographic Details
Main Authors: Guodong Zheng, Shenqian Xu, Wuxia Liu, Tingting Du, Jingfeng Zhang, Minyu Li, Chen Cai, Hong Shi
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Experimental Nanoscience
Subjects:
ret kinase
molecular dynamics simulations
drug resistance
oncogenic mutations
Online Access:http://dx.doi.org/10.1080/17458080.2021.1970141

Internet

http://dx.doi.org/10.1080/17458080.2021.1970141

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