Freeze-Dried Lopinavir-Loaded Nanostructured Lipid Carriers for Enhanced Cellular Uptake and Bioavailability: Statistical Optimization, in Vitro and in Vivo Evaluations

Freeze-Dried Lopinavir-Loaded Nanostructured Lipid Carriers for Enhanced Cellular Uptake and Bioavailability: Statistical Optimization, in Vitro and in Vivo Evaluations

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-shear homogenization method. The LPV-NLCs formulations were freeze-dried using trehalose as a cryoprotectant. In vitro release studies in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8...

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Bibliographic Details
Main Authors: Arshad Ali Khan, Jahanzeb Mudassir, Safia Akhtar, Vikneswaran Murugaiyah, Yusrida Darwis
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Pharmaceutics
Subjects:
lopinavir
lipid-based formulations
cellular uptake
factorial design
Online Access:https://www.mdpi.com/1999-4923/11/2/97

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https://www.mdpi.com/1999-4923/11/2/97

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