NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor throu...

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Bibliographic Details
Main Authors: Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Subjects:
notch signaling
NOTCH3 receptor
DLL4
JAG1
antibody drug conjugates
cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001075

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http://www.sciencedirect.com/science/article/pii/S2666379121001075

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