Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo.

Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo.

Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric cancer, and that chronic IL-11-driven STAT3 transc...

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Bibliographic Details
Main Authors: Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Giraud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4013079?pdf=render

Internet

http://europepmc.org/articles/PMC4013079?pdf=render

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