Development of automated brightfield double <it>In Situ </it>hybridization (BDISH) application for <it>HER2 g</it>ene and chromosome 17 centromere (CEN 17) for breast carcinomas and an assay performance comparison to manual dual color <it>HER2 </it>fluorescence <it>In Situ </it>hybridization (FISH)

<p>Abstract</p> <p>Background</p> <p>Human epidermal growth factor receptor 2 (<it>HER2</it>) fluorescence <it>in situ </it>hybridization (FISH) is a quantitative assay for selecting breast cancer patients for trastuzumab therapy. However, curren...

Full description

Bibliographic Details
Main Authors: Wang Lin, Dietel Manfred, Kurosumi Masafumi, Penault-Llorca Frederique, Walk Eric, Farrell Michael, Gaire Fabien, Murillo Adrian E, Lehrkamp Megan, Hauss-Wegrzyniak Beatrice, Nitta Hiroaki, Loftus Margaret, Pettay James, Tubbs Raymond R, Grogan Thomas M
Format: Article
Language:English
Published: BMC 2008-10-01
Series:Diagnostic Pathology
Online Access:http://www.diagnosticpathology.org/content/3/1/41