Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we perfo...

Full description

Bibliographic Details
Main Authors: Thean S. Chew, Nuala R. O'Shea, Gavin W. Sewell, Stefan H. Oehlers, Claire M. Mulvey, Philip S. Crosier, Jasminka Godovac-Zimmermann, Stuart L. Bloom, Andrew M. Smith, Anthony W. Segal
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
Crohn's disease
Macrophages
TNFα
Escherichia coli
Cytokines
Online Access:http://dmm.biologists.org/content/8/8/817

Internet

http://dmm.biologists.org/content/8/8/817

Similar Items