The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

PknB is an essential serine/threonine protein kinase required for mycobacterial cell division and cell-wall biosynthesis. Here we demonstrate that overexpression of the external PknB_PASTA domain in mycobacteria results in delayed regrowth, accumulation of elongated bacteria and increased sensitivit...

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Bibliographic Details
Main Authors: Obolbek Turapov, Jessica Loraine, Christopher H. Jenkins, Philippe Barthe, Daniel McFeely, Francesca Forti, Daniela Ghisotti, Dusan Hesek, Mijoon Lee, Andrew R. Bottrill, Waldemar Vollmer, Shahriar Mobashery, Martin Cohen-Gonsaud, Galina V. Mukamolova
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
mycobacterium tuberculosis
serine/threonine protein kinase
magnesium
muropeptides
pknb
pasta domain
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150025

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150025

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