The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Mast cells play a critical role in the pathogenesis of allergic asthma. Histamine is a central mediator released from mast cells through allergic reactions. Histamine plays a role in airway obstruction via smooth muscle contraction, bronchial secretion, and airway mucosal edema. However, previous cl...

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Bibliographic Details
Main Authors: Kohei Yamauchi, Masahito Ogasawara
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
airway obstruction
histamine receptor
histamine receptor 1 antagonist
histamine transporter
OCT-3
Th2 cell
allergen
IgE
innate immunity
type 2 innate lymphoid cells
allergic rhinitis
Online Access:https://www.mdpi.com/1422-0067/20/7/1733

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https://www.mdpi.com/1422-0067/20/7/1733

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