Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis

Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis

During multiple sclerosis (MS), a close link has been demonstrated to occur between inflammation and neuro-axonal degeneration, leading to the hypothesis that immune mechanisms may promote neurodegeneration, leading to irreversible disease progression. Energy deficits and inflammation-driven mitocho...

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Bibliographic Details
Main Authors: Andrea Mancini, Michela Tantucci, Petra Mazzocchetti, Antonio de Iure, Valentina Durante, Lara Macchioni, Carmela Giampà, Alessandra Alvino, Lorenzo Gaetani, Cinzia Costa, Alessandro Tozzi, Paolo Calabresi, Massimiliano Di Filippo
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Neurobiology of Disease
Subjects:
Multiple sclerosis
Mitochondrial dysfunction
Neurodegeneration
Nitric oxide
Microglia
Neuroprotective strategies
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300020

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http://www.sciencedirect.com/science/article/pii/S0969996118300020

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