Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Abstract Background Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of perinatal care. The only establishe...

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Main Authors: Christian A. Maiwald, Kim V. Annink, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Hercilia Guimarães, Tom Stiris, Luigi Cattarossi, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht, Yannique Jacobs, Axel R. Franz, for the ALBINO Study Group
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Pediatrics
Subjects:
Allopurinol
Neonatal oxygen deficiency
Hypothermia therapy
Childbirth outcome
Hypoxic-ischemic encephalopathy
Perinatal asphyxia
Online Access:http://link.springer.com/article/10.1186/s12887-019-1566-8

Internet

http://link.springer.com/article/10.1186/s12887-019-1566-8

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