Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.

Accurate predictions of T-cell epitopes would be useful for designing vaccines, immunotherapies for cancer and autoimmune diseases, and improved protein therapies. The humoral immune response involves uptake of antigens by antigen presenting cells (APCs), APC processing and presentation of peptides...

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Bibliographic Details
Main Authors: Dina Schneidman-Duhovny, Natalia Khuri, Guang Qiang Dong, Michael B Winter, Eric Shifrut, Nir Friedman, Charles S Craik, Kathleen P Pratt, Pedro Paz, Fred Aswad, Andrej Sali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6219782?pdf=render

Internet

http://europepmc.org/articles/PMC6219782?pdf=render

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