Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.

Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.

TCR-dependent and costimulation signaling, cell division, and cytokine environment are major factors driving cytokines expression induced by CD4(+) T cell activation. PEA-15 15 (Protein Enriched in Astrocyte / 15 kDa) is an adaptor protein that regulates death receptor-induced apoptosis and prolifer...

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Bibliographic Details
Main Authors: Stéphane Kerbrat, Benoit Vingert, Marie-Pierre Junier, Flavia Castellano, François Renault-Mihara, Silvina Dos Reis Tavares, Mathieu Surenaud, France Noizat-Pirenne, Jorge Boczkowski, Georges Guellaën, Hervé Chneiweiss, Sabine Le Gouvello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4552951?pdf=render

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http://europepmc.org/articles/PMC4552951?pdf=render

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