Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model

Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model

Friedreich ataxia (FRDA) is a neurodegenerative disorder characterized by neuromuscular and neurological manifestations. It is caused by mutations in the FXN gene, which results in loss of the mitochondrial protein frataxin. Endoplasmic Reticulum-mitochondria associated membranes (MAMs) are inter-or...

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Bibliographic Details
Main Authors: Laura R. Rodríguez, Pablo Calap-Quintana, Tamara Lapeña-Luzón, Federico V. Pallardó, Stephan Schneuwly, Juan A. Navarro, Pilar Gonzalez-Cabo
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
MAMs
Frataxin
Calcium
Lipid peroxidation
Vitamin E
N-acetylcysteine
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309678

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http://www.sciencedirect.com/science/article/pii/S2213231720309678

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