Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

BACKGROUND: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: Expression and activity of P-glycoprotein (P-gp), Multid...

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Bibliographic Details
Main Authors: Juan P Rigalli, Virginia G Perdomo, Marcelo G Luquita, Silvina S M Villanueva, Agostina Arias, Dirk Theile, Johanna Weiss, Aldo D Mottino, María L Ruiz, Viviana A Catania
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3521711?pdf=render

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http://europepmc.org/articles/PMC3521711?pdf=render

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