Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice.

Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice.

High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on steatosis progression. In some models of fatty liver disease, high doses of human IL-6 ameliorate the liv...

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Bibliographic Details
Main Authors: Ana Luisa Gavito, Dolores Bautista, Juan Suarez, Samir Badran, Rocío Arco, Francisco Javier Pavón, Antonia Serrano, Patricia Rivera, Juan Decara, Antonio Luis Cuesta, Fernando Rodríguez-de-Fonseca, Elena Baixeras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4917096?pdf=render

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http://europepmc.org/articles/PMC4917096?pdf=render

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