Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish

The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, whether the simple zebrafish heart can model different subtypes of cardiomyopathies, such as dilated cardiomyopathy (DCM), remains elusive. Here, we generated and characterized an inherited DCM model in...

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Bibliographic Details
Main Authors: Yonghe Ding, Alexey V. Dvornikov, Xiao Ma, Hong Zhang, Yong Wang, Matthew Lowerison, Rene R. Packard, Lei Wang, Jun Chen, Yuji Zhang, Tzung Hsiai, Xueying Lin, Xiaolei Xu
Format: Article
Language:English
Published: The Company of Biologists 2019-10-01
Series:Disease Models & Mechanisms
Subjects:
dilated cardiomyopathy
bcl2-associated athanogene 3
mtor
danio rerio
Online Access:http://dmm.biologists.org/content/12/10/dmm040154

Internet

http://dmm.biologists.org/content/12/10/dmm040154

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