Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

Seven of 15 clinical trial participants treated with a nucleoside analogue (fialuridine [FIAU]) developed acute liver failure. Five treated participants died, and two required a liver transplant. Preclinical toxicology studies in mice, rats, dogs, and primates did not provide any indication that FIA...

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Bibliographic Details
Main Authors: Dan Xu, Toshi Nishimura, Sachiko Nishimura, Haili Zhang, Ming Zheng, Ying-Ying Guo, Marylin Masek, Sara A Michie, Jeffrey Glenn, Gary Peltz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC3988005?pdf=render

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http://europepmc.org/articles/PMC3988005?pdf=render

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