Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral ischemia in mice

<p>Abstract</p> <p>Background and Purpose</p> <p>Oligodendrocyte (OL) death is important in focal cerebral ischemia. TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs undergo apoptosis during ische...

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Bibliographic Details
Main Authors: Ben Chi, Reichard Ross R, Li Lu, Candelario-Jalil Eduardo, Walker Espen J, Thompson Jeffrey F, Jalal Fakhreya Y, Yang Yi, Sang Qing-Xiang, Cunningham Lee Anna, Rosenberg Gary A
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/8/1/108

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http://www.jneuroinflammation.com/content/8/1/108

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