Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel

Male Infertility Diagnosis: Improvement of Genetic Analysis Performance by the Introduction of Pre-Diagnostic Genes in a Next-Generation Sequencing Custom-Made Panel

BackgroundInfertility affects about 7% of the general male population. The underlying cause of male infertility is undefined in about 50% of cases (idiopathic infertility). The number of genes involved in human spermatogenesis is over two thousand. Therefore, it is essential to analyze a large numbe...

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Bibliographic Details
Main Authors: Vincenza Precone, Rossella Cannarella, Stefano Paolacci, Gian Maria Busetto, Tommaso Beccari, Liborio Stuppia, Gerolamo Tonini, Alessandra Zulian, Giuseppe Marceddu, Aldo E. Calogero, Matteo Bertelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Endocrinology
Subjects:
male infertility
next-generation sequencing
genetic test
spermatogenesis defects
azoospermia
oligozoospermia
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.605237/full

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https://www.frontiersin.org/articles/10.3389/fendo.2020.605237/full

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