Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

<h4>Background</h4>Pyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens. Pyrazinamide-susceptibility test usually takes a week to have a diagnosis to guide initial therapy, implying a delay in receiving a...

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Main Authors: Rydberg Roman Supo-Escalante, Aldhair Médico, Eduardo Gushiken, Gustavo E Olivos-Ramírez, Yaneth Quispe, Fiorella Torres, Melissa Zamudio, Ricardo Antiparra, L Mario Amzel, Robert H Gilman, Patricia Sheen, Mirko Zimic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0235643

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https://doi.org/10.1371/journal.pone.0235643

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