Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export

Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export

The influenza A virus replicates in a broad range of avian and mammalian species by hijacking cellular factors and processes. Avian influenza A viruses (AIVs) generally propagated poorly in mammalian cells, but some mutants of virus-encoded RNA polymerase components, especially PB2 subunit, can over...

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Bibliographic Details
Main Authors: Xingxing Ren, Yuandi Yu, Huanan Li, Jinyu Huang, Aobaixue Zhou, Shukai Liu, Pingsheng Hu, Bo Li, Wenbao Qi, Ming Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Microbiology
Subjects:
avian influenza A virus
PB2
eIF4A3 RNA helicase
polymerase
splicing
mRNA export
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01625/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01625/full

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