Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway

Resistance to breast cancer (BCa) chemotherapy severely hampers the patient's prognosis. MicroRNAs provide a potential therapeutic prospect for BCa. In this study, the reversal function of microRNA34a (miR34a) on doxorubicin (Dox) resistance of BCa and the possible mechanism was investigated. W...

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Bibliographic Details
Main Authors: Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin, Jing Liao, Lei Wang, Jianbo Ji, Xiuli Guo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Breast cancer
miR34a
Dox
Drug resistance
Snail
Notch/NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100215X

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http://www.sciencedirect.com/science/article/pii/S221138352100215X

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