Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging.

UNLABELLED: Bioluminescence imaging is routinely performed in anesthetized mice. Often isoflurane anesthesia is used because of its ease of use and fast induction/recovery. However, general anesthetics have been described as important inhibitors of the luciferase enzyme reaction. AIM: To investigate...

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Bibliographic Details
Main Authors: Marleen Keyaerts, Isabel Remory, Vicky Caveliers, Karine Breckpot, Tomas J Bos, Jan Poelaert, Axel Bossuyt, Tony Lahoutte
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3254645?pdf=render