Alcohol exposure decreases osteopontin expression during fracture healing and osteopontin-mediated mesenchymal stem cell migration in vitro

Alcohol exposure decreases osteopontin expression during fracture healing and osteopontin-mediated mesenchymal stem cell migration in vitro

Abstract Background Alcohol consumption is a risk factor for impaired fracture healing, though the mechanism(s) by which this occurs are not well understood. Our laboratory has previously shown that episodic alcohol exposure of rodents negatively affects fracture callus development, callus biomechan...

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Bibliographic Details
Main Authors: Roman M. Natoli, Henry Yu, Megan Conti-Mica Meislin, Pegah Abbasnia, Philip Roper, Aleksandra Vuchkovska, Xianghui Xiao, Stuart R. Stock, John J. Callaci
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Bone fracture
Fracture non-union
Alcohol
Osteopontin
Integrin
Mesenchymal stem cell migration
Online Access:http://link.springer.com/article/10.1186/s13018-018-0800-7

Internet

http://link.springer.com/article/10.1186/s13018-018-0800-7

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