Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.

Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.

Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum, and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson's disease. We undertook functional and causal...

Full description

Bibliographic Details
Main Authors: Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Birgitt Schüle, Jeff Alexander, William Wallace, Glenda M Halliday, J William Langston, Scott Braxton, Ted Yednock, Thomas Shaler, Jennifer A Johnston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4149353?pdf=render

Internet

http://europepmc.org/articles/PMC4149353?pdf=render

Similar Items