Anti-diabetic effects of a phenolic-rich extract from Hypericum attenuatum Choisy in KK-Ay mice mediated through AMPK /PI3K/Akt/GSK3β signaling and GLUT4, PPARγ, and PPARα expression

Anti-diabetic effects of a phenolic-rich extract from Hypericum attenuatum Choisy in KK-Ay mice mediated through AMPK /PI3K/Akt/GSK3β signaling and GLUT4, PPARγ, and PPARα expression

In this study, we investigated anti-diabetic activities of a phenolic-rich extract from Hypericum attenuatum Choisy (HA-PRE). In vivo, 4-week treatment of HA-PRE improved hyperglycemia, obesity, glucose tolerance, and hyperinsulinism. Western blot analysis revealed that HA-PRE increased AMPKα and Ak...

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Bibliographic Details
Main Authors: Yibing Lv, Ji Hao, Chang Liu, Huiqi Huang, Yuanren Ma, Xinzhou Yang, Li Tang
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Journal of Functional Foods
Subjects:
Phenolic-rich extract
Type 2 diabetes
Hyperlipidemia
Glucose transporter 4
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461930430X

Internet

http://www.sciencedirect.com/science/article/pii/S175646461930430X

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