Intronic miR-744 Inhibits Glioblastoma Migration by Functionally Antagonizing Its Host Gene MAP2K4

Background: The second intron of Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4), an important hub in the pro-invasive MAPK pathway, harbors miR-744. There is accumulating evidence that intronic micro-RNAs (miRNAs) are capable of either supporting or restraining functional pathways of their host...

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Bibliographic Details
Main Authors: Max Hübner, Christian Ludwig Hinske, David Effinger, Tingting Wu, Niklas Thon, Friedrich-Wilhelm Kreth, Simone Kreth
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/10/11/400