Static vs. Dynamic Electrostatic Repulsion Reversed Phase Liquid Chromatography: Solutions for Pharmaceutical and Biopharmaceutical Basic Compounds

Static vs. Dynamic Electrostatic Repulsion Reversed Phase Liquid Chromatography: Solutions for Pharmaceutical and Biopharmaceutical Basic Compounds

Many efforts have been made to separate basic compounds, which are challenging to resolve in reversed phase liquid chromatography. In this process, they are strongly retained and the peak shape undergoes significant distortion. The principal origin of this has been identified with the non-negligible...

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Bibliographic Details
Main Authors: Giulia Mazzoccanti, Francesco Gasparrini, Andrea Calcaterra, Claudio Villani, Alessia Ciogli
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Separations
Subjects:
basic compounds
static ERRP
dynamic ERRP
hydrophobic cation additive
Online Access:https://www.mdpi.com/2297-8739/8/5/59

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https://www.mdpi.com/2297-8739/8/5/59

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