Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-κB/RelA Activation

Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-κB/RelA Activation

Coxiella burnetii is the causative agent of Q fever and an obligate intracellular pathogen in nature that survives and grows in a parasitophorous vacuole (PV) within eukaryotic host cells. C. burnetii promotes intracellular survival by subverting apoptotic and pro-inflammatory signaling pathways tha...

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Bibliographic Details
Main Authors: Saugata Mahaptra, Brandi Gallaher, Sydni Caet Smith, Joseph G Graham, Daniel E Voth, Edward I Shaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Coxiella burnetii
Q Fever
NF-κB
Obligate intracellular
Type four secretion system
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00188/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00188/full

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