Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.

Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.

Current experiments likely cover only a fraction of all protein-protein interactions. Here, we developed a method to predict SH2-mediated protein-protein interactions using the structure of SH2-phosphopeptide complexes and the FoldX algorithm. We show that our approach performs similarly to experime...

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Bibliographic Details
Main Authors: Ignacio E Sánchez, Pedro Beltrao, Francois Stricher, Joost Schymkowitz, Jesper Ferkinghoff-Borg, Frederic Rousseau, Luis Serrano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2271153?pdf=render

Internet

http://europepmc.org/articles/PMC2271153?pdf=render

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