A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

The ASCT1 transporter of the SLC1 family is largely involved in equilibration of neutral amino acids’ pools across the plasma membrane and plays a prominent role in the transport of both L- and D-isomers of serine, essential for the normal functioning of the central nervous system in mammals. A numb...

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Bibliographic Details
Main Authors: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J. Marrink, Cornelius Gati, Albert Guskov
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Membrane transporter
Solute carrier
Cryo-EM
Molecular dynamics
ASCT1
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021004001

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http://www.sciencedirect.com/science/article/pii/S2001037021004001

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