The Cep57-pericentrin module organizes PCM expansion and centriole engagement
Centriole disengagement occurs towards mitotic exit and involves cleavage of pericentrin, a component of the pericentriolar material. Here the authors show that depletion of the centrosomal protein Cep57 leads to precocious centriole disengagement, and that Cep57 binds pericentrin.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08862-2 |