TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients

TCR activation mimics CD127lowPD-1high phenotype and functional alterations of T lymphocytes from septic shock patients

Abstract Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death. As interleukin-7 (IL-7) is currently tested in clinical trials to reverse these dysfunc...

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Bibliographic Details
Main Authors: Julie Mouillaux, Camille Allam, Morgane Gossez, Thomas Uberti, Benjamin Delwarde, Jack Hayman, Thomas Rimmelé, Julien Textoris, Guillaume Monneret, Estelle Peronnet, Fabienne Venet
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Critical Care
Subjects:
Sepsis
Exhaustion
IL-7
Immunosuppression
CD127
PD-1
Online Access:http://link.springer.com/article/10.1186/s13054-018-2305-5

Internet

http://link.springer.com/article/10.1186/s13054-018-2305-5

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